AREG Antibody is a Rabbit Polyclonal antibody against AREG. Amphiregulin (AREG) is one of the ligands of the epidermal growth factor receptor (EGFR). AREG plays a central role in mammary gland development and branching morphogenesis in organs and is expressed both in physiological and in cancerous tissues. The AREG protein is synthesized as a 252-amino acid transmembrane precursor, pro-AREG. At the plasma membrane, pro-AREG is subjected to sequential proteolytic cleavages within its ectodomain and is then released as the soluble AREG protein. Depending on the cell type and microenvironment, AREG can be produced in multiple cellular and mature forms using alternative pro-AREG cleavage sites and glycosylation motifs.

Target	Amphiregulin (AREG)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 20-252 of human Amphiregulin.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P15514 (UniProt, ExPASy)
UniProt Secondary AC	Q5U026
UniProt Entry Name	AREG_HUMAN
Gene Symbol	AREG
GeneID	374
NCBI Accession	NP_001648.1
KEGG	hsa:374
String	9606.ENSP00000379097
Molecular Weight	Calculated MW: 28 kDa Observed MW: 43 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Amphiregulin (AREG)