ALDH2 belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Asians have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Asians than among Caucasians could be related to the absence of the mitochondrial isozyme.

Target	Aldehyde Dehydrogenase, Mitochondrial (ALDH2)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/2000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 318-347 amino acids from the Central region of human ALDH2.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P05091 (UniProt, ExPASy)
UniProt Secondary AC	B4DW54, E7EUE5, Q03639, Q6IB13, Q6IV71
UniProt Entry Name	ALDH2_HUMAN
NCBI Accession	NP_000681.2 NP_001191818.1
KEGG	hsa:217
String	9606.ENSP00000261733
Molecular Weight	Calculated MW: 56.4 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Rat ALDH2.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Aldehyde Dehydrogenase, Mitochondrial (ALDH2)