產(chǎn)品詳情
簡單介紹：
Anti-FOLH1 antibody (50-150) (STJ11103877)
詳情介紹：
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Glutamate Carboxypeptidase 2 (50-150) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:100-1:500 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FOLH1 |
| Gene ID: | 2346 |
| Uniprot ID: | FOLH1_HUMAN |
| Immunogen Region: | 50-150 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human PSMA/FOLH1 (NP_004467.1). |
| Immunogen Sequence: | TNITPKHNMKAFLDELKAEN IKKFLYNFTQIPHLAGTEQN FQLAKQIQSQWKEFGLDSVE LAHYDVLLSYPNKTHPNYIS IINEDGNEIFNTSLFEPPPP G |
| Tissue Specificity | Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney. Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-9 is specifically expressed in prostate cancer. |
| Post Translational Modifications | The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis. The N-terminus is blocked. |
| Function | Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression. Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC. |
| Protein Name | Glutamate Carboxypeptidase 2 Cell Growth-Inhibiting Gene 27 Protein Folate Hydrolase 1 Folylpoly-Gamma-Glutamate Carboxypeptidase Fgcp Glutamate Carboxypeptidase Ii Gcpii Membrane Glutamate Carboxypeptidase Mgcp N-Acetylated-Alpha-Linked Acidic Dipeptidase I Naaladase I Prostate-Specific Membrane Antigen Psm Psma Pteroylpoly-Gamma-Glutamate Carboxypeptidase |
| Database Links | Reactome: R-HSA-8963693 |
| Cellular Localisation | Cell Membrane Single-Pass Type Ii Membrane Protein Isoform Psma': Cytoplasm |
| Alternative Antibody Names | Anti-Glutamate Carboxypeptidase 2 antibody Anti-Cell Growth-Inhibiting Gene 27 Protein antibody Anti-Folate Hydrolase 1 antibody Anti-Folylpoly-Gamma-Glutamate Carboxypeptidase antibody Anti-Fgcp antibody Anti-Glutamate Carboxypeptidase Ii antibody Anti-Gcpii antibody Anti-Membrane Glutamate Carboxypeptidase antibody Anti-Mgcp antibody Anti-N-Acetylated-Alpha-Linked Acidic Dipeptidase I antibody Anti-Naaladase I antibody Anti-Prostate-Specific Membrane Antigen antibody Anti-Psm antibody Anti-Psma antibody Anti-Pteroylpoly-Gamma-Glutamate Carboxypeptidase antibody Anti-FOLH1 antibody Anti-FOLH antibody Anti-NAALAD1 antibody Anti-PSM antibody Anti-PSMA antibody Anti-GIG27 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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